Fluorocarbon derivatives of nitrogen. Part 11. Synthesis of some 2-(trifluoromethyl)imidazo[1,2-a]pyridines from trifluoroacetonitrile was written by Banks, Ronald Eric;Thomson, Julie. And the article was included in Journal of Fluorine Chemistry in 1984.HPLC of Formula: 17281-59-3 This article mentions the following:
The title compound (I; R = Me3CO2C), prepared from CF3CN and pyridinium t-butoxycarbonylmethylide, reacts smoothly with CF3CO2H to give the acid (I; R = HO2C), which was decarboxylated to I (R = H) on heating. The cyano derivative (I; R = cyano) can be obtained via treatment of CF3CN with pyridinium cyanomethylide, which is sufficiently reactive to effect nucleophilic displacement of fluorine from pentafluoropyridine under mild conditions to give II. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3HPLC of Formula: 17281-59-3).
1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 17281-59-3