ãA B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Libraryã?was written by Bao, Yapeng; Deng, Zongfa; Feng, Jing; Zhu, Weiwei; Li, Jin; Wan, Jinqiao; Liu, Guansai. COA of Formula: C6H4N2O4 And the article was included in Organic Letters on August 21 ,2020. The article conveys some information:
Indazolone cores are among the most common structural components in medicinal chem. and can be found in many biol. active mols. In this report, a mild and efficient approach to 2-substituted indazolones via B2(OH)4-mediated reductive N-N bond formation is developed. This strategy features mild conditions, no request for a metal catalyst, and a wide scope for both aliphatic and aromatic amines. Meanwhile, this method was further successfully applied on DNA to construct indazolone cores for a DNA-encoded library. This will enable the production of a very attractive indazolone-cored library from simple amines and scaffolds, which will provide considerable diversity. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3COA of Formula: C6H4N2O4)
3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C6H4N2O4