In 2022,Baran, Andrei; Babkova, Mariia; Petkus, Jana; Shubin, Kirill published an article in Applied Organometallic Chemistry. The title of the article was 《Suzuki-Miyaura arylation of 2,3-, 2,4-, 2,5-, and 3,4-dibromothiophenes》.Safety of Pyridin-3-ylboronic acid The author mentioned the following in the article:
A convenient and general method for Suzuki-Miyaura double cross-coupling of boronic acid with dibromothiophenes was developed to form diarylthiophenes I [Ar = Ph, 4-ClC6H4, 4-NCC6H4, etc.] using a simple and cheap catalytic system Pd(OAc)2/PPh3 in 95% EtOH. The overall efficiency of the catalytic process and slight excess of boronic acids allowed to suppress formation of side products and significantly simplify the purification of products. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of Pyridin-3-ylboronic acid