《Influence of Zinc on the Acute Changes in Erythropoietin and Proinflammatory Cytokines with Hypoxia》 was written by Baranauskas, Marissa N.; Powell, Joseph; Fly, Alyce D.; Martin, Bruce J.; Mickleborough, Timothy D.; Paris, Hunter L.; Chapman, Robert F.. Formula: C6H5NO2This research focused onzinc erythropoietin proinflammatory cytokine hypoxia; acclimatization; altitude training; antioxidants; interleukin-6; nutritional strategies. The article conveys some information:
Baranauskas, Marissa N., Joseph Powell, Alyce D. Fly, Bruce J. Martin, Timothy D. Mickleborough, Hunter L. Paris, and Robert F. Chapman. Influence of zinc on the acute changes in erythropoietin and proinflammatory cytokines with hypoxia. High Alt Med Biol. 22: 148-156, 2021. Considerable, unexplained, interindividual variability characterizes the erythropoietin (EPO) response to hypoxia, which can impact hematol. acclimatization for individuals sojourning to altitude. Zinc supplementation has the potential to alter EPO by attenuating increases in inflammation and oxidative stress. Yet, the application of such an intervention has not been evaluated in humans. In this proof-of-concept study, we aimed to evaluate the EPO and inflammatory responses to acute hypoxia in human participants following chronic zinc supplementation. Nine phys. active participants (men n = 5, women n = 4, age 28 ± 4 years, height 176 ± 11 cm, mass 77 ± 21 kg) were exposed to 12 h of normobaric hypoxia simulating an altitude of 3,000 m (FiO2 = 0.14) before and after 8 wk of supplementation with 40 mg/day of elemental zinc from picolinate. Blood samples for subsequent anal. of serum zinc, EPO, superoxide dismutase (extracellular superoxide dismutase [EC-SOD]), C-reactive protein (CRP), and proinflammatory cytokines were obtained pre- and postsupplementation and exposure to hypoxia. After zinc supplementation, EPO increased by 64.9 ± 36.0% (mean ± standard deviation) following 12 h of hypoxia, but this response was not different from presupplementation (70.8 ± 46.1%). Considerable interindividual (range: -1% to +208%) variability was apparent in the acute EPO response. While most markers of inflammation did not change with hypoxia, interleukin-6 concentrations increased from 1.17 ± 0.05 to 1.97 ± 0.32 pg/mL during the final 6 h. The acute EPO response at 12 h was not related to changes in serum zinc, EC-SOD, CRP, or proinflammatory cytokines. Zinc supplementation does not influence the acute EPO or inflammatory response with short-term exposure to moderate levels of normobaric hypoxia (3,000 m) in apparently healthy young adults. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Formula: C6H5NO2)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Formula: C6H5NO2