Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Safety of 5-Bromo-2-fluoropyridine.
Barlaam, Bernard;Cadogan, Elaine;Campbell, Andrew;Colclough, Nicola;Dishington, Allan;Durant, Stephen;Goldberg, Kristin;Hassall, Lorraine A.;Hughes, Gareth D.;MacFaul, Philip A.;McGuire, Thomas M.;Pass, Martin;Patel, Anil;Pearson, Stuart;Petersen, Jens;Pike, Kurt G.;Robb, Graeme;Stratton, Natalie;Xin, Guohong;Zhai, Baochang research published 《 Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors》, the research content is summarized as follows. The authors report the discovery of a novel series of 3-cinnoline carboxamides as highly potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitors. Optimization of this series focusing on potency and physicochem. properties (especially permeability) led to the identification of compound 21 (6-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-N-methyl-4-[[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethyl]amino]-3-cinnolinecarboxamide), a highly potent ATM inhibitor (ATM cell IC50 0.0028 μM) with excellent kinase selectivity and favorable physicochem. and pharmacokinetics properties. In vivo, 21 in combination with irinotecan showed tumor regression in the SW620 colorectal tumor xenograft model, superior inhibition to irinotecan alone. Compound 21 was selected for preclin. evaluation alongside AZD0156.
766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Safety of 5-Bromo-2-fluoropyridine