Barraclough, Paul published the artcileInotropic ‘A’ ring substituted sulmazole and isomazole analogs, Category: pyridine-derivatives, the publication is Journal of Medicinal Chemistry (1990), 33(8), 2231-9, database is CAplus and MEDLINE.
A series of “A” ring substituted sulmazole I [R = 4-, 5-, 6-MeO, 5-NO2, 5-Cl, 5-Me, 5-Ac; X = S, S(O), O] and isomazole analogs II [R = 2-, 5-, 6-MeO, 5-NH2, 5-NO2; X = S, S(O), O] were prepared and evaluated as inotropic agents. Thus, 5-methoxy-2,3-pyridinediamine was cyclized with 2-methoxy-4-(methylthio)benzoic acid to give I (R = 5-MeO, X = S), which was oxidized to give I [R = 5-MeO, X = S(O)]. PKA‘s, protonation sites, and log P values were measured for selected compounds and their electronic properties were calculated No simple correlation between inotropic activity and pKA, protonation site, or log P value was observed However, in vitro inotropism did correlate with the calculated charge d. of the “B” ring imidazo nitrogen atom. The 6-position of sulmazole appeared to be the most tolerant toward substituents, the 6-amino derivative I [R = 6-NH, X = S(O)] being a more potent inotrope than sulmazole itself. 4-Methoxyisomazole had comparable in vivo inotropic properties to those of isomazole.
Journal of Medicinal Chemistry published new progress about 33631-04-8. 33631-04-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Ether, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, Category: pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem