Basu, Sourav; Middya, Sandip; Banerjee, Monali; Ghosh, Rajib; Pryde, David C.; Yadav, Dharmendra B.; Shrivastava, Ritesh; Surya, Arjun published the artcile< The discovery of potent small molecule cyclic urea activators of STING>, Application In Synthesis of 387350-39-2, the main research area is cyclic urea preparation interferon stimulator activation; Immune oncology; Innate immunity; Interferon; STING; cGAS.
STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyclic STING ligands. We describe here the discovery of 3,4-dihydroquinazolin-2(1H)-one based 6,6-bicyclic heterocyclic agonists of human STING that activate all known human variants of STING with high potency.
European Journal of Medicinal Chemistry published new progress about Heterocyclic compounds, nitrogen Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 387350-39-2 belongs to class pyridine-derivatives, and the molecular formula is C7H7F3N2, Application In Synthesis of 387350-39-2.