Reaction of 2-pyridones with benzyne was written by Bauer, Ludwig;Bell, Charles Leighton;Wright, George Edward. And the article was included in Journal of Heterocyclic Chemistry in 1966.Recommanded Product: 4783-68-0 This article mentions the following:
When 1-methyl-2-pyridone (I) was allowed to react with diazotized anthranilic acid (II) under conditions which generate benzyne (Friedman and Logullo, CA 59, 1556a), the adduct (III) was obtained in 10% yield, with acridone as a by product, which also forms from II under identical conditions even in the absence of I. On pyrolysis at 200鎺? III forms naphthalene. When benzyne was generated from PhCl and NaNH2 (Leake and Levine, CA 53, 16048f), the reaction with I gave 1-methyl-3-phenyl-2-pyridone in 5.4% yield, with 1,1′-dimethyl-2,2′-bipyridine-6,6′-dioneas by-product [which was also synthesized from 2,2′-bipyridine by quaternizing it with Me2SO4 to the bis(methosulfate), followed by the Decker oxidation with K3Fe(CN)6]. It also forms in small amounts in the reaction of I with NaNH2 in liquid NH3 in the absence of PhCl. In liquid NH3, ring opening of I was observed to give MeNHCH:CHCH:CHCONH2 in 6% yield. In the reaction of 2-pyridone with benzyne (from II) no Diels-Alder adduct could be isolated, the products found being 2-phenoxypyridine (3.9%), 1-phenyl-2-pyridone, and a little acridone. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 4783-68-0