Baxevanis, Fotios published the artcileInvestigation of drug partition kinetics to fat in simulated fed state gastric conditions based on drug properties, Recommanded Product: 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is simulated gastric fluid fat drug partition kinetics; Drug partition; Fed state; Food effect; Partial least squares regression; Physicochemical properties.
The presence of fat in the gastric environment can affect the pharmacokinetic behavior of drugs with mechanisms which have not been yet fully understood. The objective of the current study was to assess the drug partition to the lipid part of the fed gastric content under different emulsification conditions, using in vitro discriminating setups. The model drugs used in the study were selected on the basis of different physicochem. properties (lipophilicity, ionization, mol. weight and aqueous solubility) and different food effect observed in in vivo human studies. Fed State Simulated Gastric Fluid prepared with skimmed milk (FeSSGFsk) and anhydrous milk fat were used as surrogates for the aqueous and fat portions of the fed gastric environment resp. An optimized biphasic model was developed so as to predict the differences in partition rate constants to fat, for model drugs of a wide range of the properties mentioned above. The exptl. data and the use of statistical anal. revealed that mol. weight, mol. weight and log D pH5 interaction and neg. food effect act as neg. factors to the rate constants of fat partition, while absence of food effect and logD pH 5interaction with aqueous solubility affect the rate constants of partition to fat favorably.
European Journal of Pharmaceutical Sciences published new progress about Anionic surfactants. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Recommanded Product: 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.