Baydas, Yasemin published the artcileAsymmetric reduction of aromatic heterocyclic ketones with bio-based catalyst Lactobacillus kefiri P2, Related Products of pyridine-derivatives, the publication is Chemical Papers (2021), 75(3), 1147-1155, database is CAplus.
In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asym. reduction of prochiral ketones RC(O)R1 (R = pyridin-2-yl, 2H-1,3-benzodioxol-5-yl, furan-2-yl, etc.; R1 = Me, Ph, pyridin-2-yl) to chiral secondary alcs R/S-RCH(R1)OH. Secondary chiral carbinols were obtained by asym. bioreduction of different prochiral substrates with results up to > 99% enantiomeric excess (ee). The compound R/S-RCH(R1)OH (R = pyridin-2-yl, R1 = Me (I)) which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective β-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70 g of I in enantiomerically pure form was obtained in 96% yield. Also, production of I in terms of yield and gram scale through catalytic asym. reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcs. compared to chem. processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis.
Chemical Papers published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Related Products of pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem