Beak, Peter; Lee, Jae-Keun; McKinnie, B. Gary published the artcile< Methylation of protomeric ambident nucleophiles with methyl fluorosulfonate: a regiospecific reaction>, Application of C6H6ClNO, the main research area is methylation methyl fluorosulfate regiospecificity; nucleophile methylation regiospecific.
Methylation of 15 protomeric ambident nucleophiles with MeOSO2F occurred regiospecifically at the heteroatom remote from the mobile proton. In most cases the fluorosulfonate salts thus obtained were isolated, identified by NMR spectroscopy, and converted to the neutral methylated derivatives by aqueous base. The compounds studied include 5 of the 9 possible systems X:YZH ⇌ HXY:Z in which Y is C and X and Z are O, N and/or S. In 12 cases the reaction was synthetically useful, although it was sometimes necessary to remove the excess MeOSO2F prior to treatment with base. Three cases give mixtures of methylated products, a result established for the case of 2-pyridone as due to proton transfer from the initial regiospecifically-formed salt.
Journal of Organic Chemistry published new progress about 13472-84-9. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Application of C6H6ClNO.