In 2019,Organic Letters included an article by Begam, Hasina Mamataj; Choudhury, Rajarshee; Behera, Ashok; Jana, Ranjan. Electric Literature of C6H5NO2. The article was titled 《Copper-Catalyzed Electrophilic Ortho C(sp2)-H Amination of Aryl Amines: Dramatic Reactivity of Bicyclic System》. The information in the text is summarized as follows:
A practical copper-catalyzed, 2-picolinamide-directed ortho C-H amination of anilines with benzoyl-protected hydroxylamines was disclosed that proceeds smoothly without any external stoichiometric oxidant or additives. Remarkably, besides anilines, bicyclic naphthyl or heterocyclic amines furnished amination products with five- and six-membered cyclic and acyclic amines at the ortho position selectively. This electrophilic C-H amination also proceeds smoothly in water under slightly modified reaction conditions.Picolinic acid(cas: 98-98-6Electric Literature of C6H5NO2) was used in this study.
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Electric Literature of C6H5NO2