Synthesis, Crystal Structure, and Antibacterial Activity of 1,2,4-Triazoles and 1,2,4-Triazol-3-one was written by Ben Salah, Bochra;Chaari, Najla;Rekik, Awatef;Ben Hsouna, Anis;Trigui, Mohamed;Kossentini, Mohamed. And the article was included in Journal of Heterocyclic Chemistry in 2015.Electric Literature of C5H6ClN This article mentions the following:
A straightforward method has been developed for the synthesis of 1,2,4-triazol-3-one 3 and 1,2,4-triazoles 6a, 6b, 6c, 6d starting from N1-substituted-N1-tosylhydrazonates 2 and hydrazine monohydrate. This methodol. affords a number of 1,2,4-triazol-3-one 3 and 1,2,4-triazoles 6a, 6b, 6c, 6d in reasonable yields. The structures of all new compounds were elucidated using IR, 1H and 13C NMR, high-resolution mass spectrometry, elemental anal., and the X-ray crystallog. (for compounds 3 and 6a). Some of the newly synthesized compounds were screened for their antibacterial activity. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Electric Literature of C5H6ClN).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Electric Literature of C5H6ClN