Rapid synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under microwave irradiation was written by Bentiss, Fouad;Lagrenee, Michel;Barbry, Didier. And the article was included in Synthetic Communications in 2001.Recommanded Product: 15420-02-7 This article mentions the following:
A number of sym. 2,5-disubstituted 1,3,4-oxadiazoles I (Ar = Ph, 2-ClC6H4, 4-pyridyl, etc.) are quickly prepared by the reaction of aromatic acids ArCO2H with hydrazine dihydrochloride in a mixture of orthophosphoric acid and phosphorus pentoxide under microwave irradiation In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 15420-02-7).
2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 15420-02-7