伪-Helix in Cystathionine 尾-Synthase Enzyme Acts as an Electron Reservoir was written by Bhatt, Aashish;Mukhopadhyaya, Aritra;Ali, Ehesan Md.. And the article was included in Journal of Physical Chemistry B in 2022.COA of Formula: C8H10NO6P The following contents are mentioned in the article:
The modulation of electron d. at the Pyridoxal 5鈥?phosphate (PLP) catalytic center, because of charge transfer across the 伪-helix/PLP interface, is the determining factor for the enzymic activities in the human Cystathionine 尾-Synthase (hCBS) enzyme. Applying d. functional theory calculations, in conjunction with the real space d. anal., we investigated the charge d. delocalization across the entire heme-伪-helix-PLP electron communication channels. The electron delocalization due to hydrogen bonds at the heme/伪-helix and 伪-helix/PLP interfaces are found to be extended over a very long range, as a result of redistribution of electron densities of the cofactors. Moreover, the internal hydrogen bonds of 伪-helix that are crucial for its secondary structure also participate in the electron redistribution through the structured hydrogen-bond network. 伪-Helix is found to accumulate the electron d. at the ground state from both of the cofactors and behaves as an electron reservoir for catalytic reaction at the electrophilic center of PLP. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7COA of Formula: C8H10NO6P).
(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C8H10NO6P