伪-Helix in cystathionine 尾-synthase enzyme acts as an electron reservoir was written by Bhatt, Aashish;Mukhopadhyaya, Aritra;Ali, Ehesan Md.. And the article was included in Journal of Physical Chemistry B in 2022.Related Products of 54-47-7 The following contents are mentioned in the article:
The modulation of electron d. at the pyridoxal 5′-phosphate (PLP) catalytic center, because of charge transfer across the 伪-helix/PLP interface, is the determining factor for the enzymic activities in the human cystathionine 尾-synthase (hCBS) enzyme. Applying d. functional theory calculations, in conjunction with the real space d. anal., we investigated the charge d. delocalization across the entire heme-伪-helix-PLP electron communication channels. The electron delocalization due to hydrogen bonds at the heme/伪-helix and 伪-helix/PLP interfaces are found to be extended over a very long range, as a result of redistribution of electron densities of the cofactors. Moreover, the internal hydrogen bonds of 伪-helix that are crucial for its secondary structure also participate in the electron redistribution through the structured hydrogen-bond network. 伪-Helix is found to accumulate the electron d. at the ground state from both of the cofactors and behaves as an electron reservoir for catalytic reaction at the electrophilic center of PLP. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Related Products of 54-47-7).
(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 54-47-7