Synthesis and hypoglycemic activity of pyridylalcohols was written by Blank, Benjamin;DiTullio, Nicholas W.;Krog, Arnold J.;Saunders, Harry L.. And the article was included in Journal of Medicinal Chemistry in 1979.Application of 3718-65-8 This article mentions the following:
The title and related compounds I (R = H, Me, CH2OH, etc.; R1 = H, CO2H, CH2OH, Me, etc.; R2 = H, CH2OH, Me, etc.) were prepared and tested orally for hypoglycemic activity in 48-h fasted rats. In vitro studies were carried out on rat kidney cortex. 3-(3-Methyl-2-pyridyl)propionic acid [70580-10-8] showed the highest hypoglycemia 4 or 5 h after dosing, however it caused a concomitant increase of hepatic triglycerides and(or) death. 3-Methylpicolinic acid [4021-07-2] and 3-(3-methyl-2-pyridyl)lactic acid-HCl [70580-12-0] did not effect the glycemic levels, whereas 3-(3-methyl-2-pyridyl)-2-propenoic acid [70580-13-1] caused a slight rise in these levels. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application of 3718-65-8).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 3718-65-8