Blank, Benjamin; DiTullio, Nicholas W.; Miao, Clara K.; Owings, Franklin F.; Gleason, John G.; Ross, Stephen T.; Berkoff, Charles E.; Saunders, Harry L.; Delarge, J.; Lapiere, C. L. published the artcile< Mercaptopyridinecarboxylic acids. Synthesis and hypoglycemic activity>, Application In Synthesis of 53636-56-9, the main research area is hypoglycemia mercaptopyridinecarboxylic acid; picolinic nicotinic mercapto hypoglycemic; gluconeogenesis mercaptopyridinecarboxylate.
More than 50 title compounds, isomers, analogs, and derivatives were prepared and tested for hypoglycemic activity in 48 hr fasted rats. 3-Mercaptopicolinic acid (I) [14623-54-2], and its acetate (II) [39561-87-0] and methyl ester (III) [39561-86-9] gave significant hypoglycemia at a dose of 300 mg/kg, i.p., and were effective at lower doses or administered orally. P-methoxybenzyl mercaptan is described as a novel sulfurating agent to introduce a protected mercapto group. Structure-activity relations and the role of gluconeogenesis in the observed hypoglycemia were discussed.
Journal of Medicinal Chemistry published new progress about Gluconeogenesis. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Application In Synthesis of 53636-56-9.