In 2022,Boiledieu, William; De Abreu, Maxime; Cuyamendous, Claire; Lamaa, Diana; Belmont, Philippe; Brachet, Etienne published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Photoredox synthesis of 6- and 7-membered ring scaffolds via N-centered radicals》.Electric Literature of C6H4BrNO The author mentioned the following in the article:
N-Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds Their synthesis has been considered as an important research field. In this work authors report the access to 6- and 7-membered rings via a photoinduced strategy. To authors knowledge, this work represents the first example of photo-induced 7-endo-trig cyclization with N-centered radicals. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H4BrNO