Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC was written by Borlinghaus, Niginia;Ansari, Tharique N.;Braje, Leon H.;Ogulu, Deborah;Handa, Sachin;Wittmann, Valentin;Braje, Wilfried M.. And the article was included in Green Chemistry in 2021.Electric Literature of C6H3FN2 This article mentions the following:
The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enabled nucleophilic aromatic substitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitated a broad functional group tolerance that was utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent revealed the greenness and sustainability of the methodol. presented herein. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Electric Literature of C6H3FN2).
6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Electric Literature of C6H3FN2