The author of 《Preparation and characterization of PEPPSI-palladium N-heterocyclic carbene complexes using benzimidazolium salts catalyzed Suzuki-Miyaura cross coupling reaction and their antitumor and antimicrobial activities》 were Boubakri, Lamia; Dridi, Khaireddine; Sulaiman Al-Ayed, Abduallah; Ozdemir, Ismail; Yasar, Sedat; Hamdi, Naceur. And the article was published in Journal of Coordination Chemistry in 2019. Reference of 2,6-Dibromopyridine The author mentioned the following in the article:
New palladium complexes were efficiently synthesized from the reaction of benzimidazolium salts 2a-e, potassium carbonate (K2CO3) and palladium chloride (PdCl2) in pyridine (for 3a-e). The catalytic activity of these complexes in a catalytic system including palladium complexes and K2CO3 in DMF-H2O was evaluated in Suzuki-Miyaura cross-coupling reactions of aryl bromides and chlorides with phenylboronic acid. The authors’ novel complexes show excellent catalytic activities with high turnover numbers (TON) and high turnover frequencies (TOF) (e.g. for the Suzuki-Miyaura reaction: TON up to 370 and TOF up to 123.3 h-1). Both benzimidazolium salts 2a-e and complexes 3 were characterized using spectroscopic data and elemental anal. The antimicrobial activity of the N-heterocyclic carbene palladium complexes 3a-e varies with the nature of the ligands. Also, the IC50 values of both, complexes (3a-e) and benzimidazoles 2a-e, were determined The new palladium complexes were screened for their antitumor activity. Complexes 3e and 3d exhibited the highest antitumor effect with IC50 values 6.85 μg/mL against MCF-7 and 10.75 μg/mL against T47D, resp. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Reference of 2,6-Dibromopyridine) was used in this study.
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Reference of 2,6-Dibromopyridine