Bourbeau, Matthew P.; Ashton, Kate S.; Yan, Jie; St. Jean, David J. published the artcile< Nonracemic Synthesis of GK-GKRP Disruptor AMG-3969>, Recommanded Product: tert-Butyl (5-aminopyridin-2-yl)carbamate, the main research area is AMG3969 nonracemic preparation glucokinase glucokinase regulatory protein disruptor.
A nonracemic synthesis of the glucokinase-glucokinase regulatory protein disruptor AMG-3969 (I) is reported. Key features of the synthetic approach are an asym. synthesis of the 2-alkynyl piperazine core via a base-promoted isomerization and a revised approach to the synthesis of the aminopyridinesulfonamide with an improved safety profile.
Journal of Organic Chemistry published new progress about Isomerization. 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Recommanded Product: tert-Butyl (5-aminopyridin-2-yl)carbamate.