Breitenbach, Benjamin B.; Steiert, Elena; Konhaeuser, Matthias; Vogt, Lea-Marie; Wang, Yujen; Parekh, Sapun H.; Wich, Peter R. published the artcile< Double stimuli-responsive polysaccharide block copolymers as green macrosurfactants for near-infrared photodynamic therapy>, Application In Synthesis of 2127-03-9, the main research area is polysaccharide copolymer surfactant photodynamic therapy nearinfrared radiation.
The NIR absorbing photosensitizer phthalocyanine zinc (PC(Zn)) was stabilized in aqueous media as water-dispersible nanoparticles with a reduction- and pH-responsive full polysaccharide block copolymer. A cellular uptake and also photo switchable intracellular activity of the cargo upon irradiation at wavelengths in the near IR region were shown. The block copolymer was synthesized by applying a copper-free click strategy based on a thiol exchange reaction, creating an amphiphilic double-stimuli-responsive mixed disulfide. The dual-sensitive polysaccharide micelles represent a non-toxic and biodegradable green macrosurfactant for the delivery of phthalocyanine zinc. By encapsulation into micellar nanoparticles, the bioavailability of PC(Zn) increased significantly, enabling smart photodynamic therapy for future applications in cancer-related diseases.
Soft Matter published new progress about Bioavailability. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.