In 2016,Bremer, Paul T.; Xue, Song; Janda, Kim D. published 《Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 29682-15-3 The information in the text is summarized as follows:
In developing small-mol. inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC), substituted picolinic acids were identified. Extensive investigation into the SAR of the picolinic acid scaffold revealed 5-(1-butyl-4-chloro-1H-indol-2-yl)picolinic acid (I), which possessed low micromolar activity against BoNT/A. Kinetic and docking studies demonstrated binding of I to the β-exosite: a largely unexplored site on the LC that holds therapeutic relevance for botulism treatment. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 29682-15-3