Electric Literature of 1254473-66-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1254473-66-9, name is 1-(3,5-Dichloropyridin-4-yl)ethanol, molecular formula is C7H7Cl2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate 11Freshly activated 4A molecular sieves (7.08 g) and NMO (5.53 g, 47.3 mmol) were added to a stirred solution of Intermediate 10 (3.63 g, 18.9 mmol) in DCM (125 ml). After 15 minutes TPAP (332 mg, 0.945 mmol) was added and the mixture was stirred at rt for 45 minutes. The reaction mixture was filtered through Celite and the filtrate was concentrated. The residue was purified by flash column chromatography on silica gel in 5:1 petrol-ethyl acetate to give a yellow oil (2.57 g, 72%). H NMR (400 MHz, DMSO-de) delta ppm 2.59 (s, 3 H), 8.76 (s, 2 H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1254473-66-9, 1-(3,5-Dichloropyridin-4-yl)ethanol.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; CHAN, Brayn; ESTRADA, Anthony; SWEENEY, Zachary; MCIVER, Edward Giles; WO2011/141756; (2011); A1;,
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