Related Products of 1256785-86-0 ,Some common heterocyclic compound, 1256785-86-0, molecular formula is C7H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 1-(4-aminopyridin-2-yl)ethan-1-one (29.3, 5 g, 36.72 mmol) in ACN/THF (1:1 (v/v), 50 mL) and pyridine (4.74 g, 59.92 mmol) at 0 C. was added dropwise phenyl chloroformate (4.68 g, 29.89 mmol). The resulting solution was stirred for 2 h at room temperature. The resulting mixture was concentrated under vacuum and washed with ether (2*30 mL) to provide the desired product as a yellow solid (9 g, crude), which was used as is without further purification. LC-MS (ES, m/z): 257 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1256785-86-0, its application will become more common.
Reference:
Patent; MyoKardia, Inc.; Oslob, Johan; Aubele, Danielle; Kim, Jae; McDowell, Robert; Song, Yonghong; Sran, Arvinder; Zhong, Min; (120 pag.)US2016/243100; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem