As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100202-78-6, name is 2-(Bromomethyl)-6-fluoropyridine, molecular formula is C6H5BrFN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-(Bromomethyl)-6-fluoropyridine
General procedure: Hexamethylenetetramine (159 mg, 1.13 mmol, 1.0 eq.) was added under stirring to a solution of 10-6a or 10-6b (1.0 eq.) in chloroform (15 mL). The resulting mixture was stirred at 50C for 1 hour. After cooling to rt, the solvent was removed under reduced pressure. The residue was dissolved with ethanol (10 mL) and concentrated hydrochloric acid (0.5 mL) was added. This mixture was stirred at 50C for 2 hours and at room temperature overnight. The solvent was then evaporated under reduced pressure to give the desired crude products 10a (white solid) or 10b (yellow solid) which were used in the next step without further purification.
With the rapid development of chemical substances, we look forward to future research findings about 100202-78-6.
Reference:
Article; Wenzel, Barbara; Liu, Jianrong; Dukic-Stefanovic, Sladjana; Deuther-Conrad, Winnie; Teodoro, Rodrigo; Ludwig, Friedrich-Alexander; Chezal, Jean-Michel; Moreau, Emmanuel; Brust, Peter; Maisonial-Besset, Aurelie; Bioorganic Chemistry; vol. 86; (2019); p. 346 – 362;,
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