Adding a certain compound to certain chemical reactions, such as: 10128-72-0, Methyl 3-hydroxyisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H7NO3, blongs to pyridine-derivatives compound. Formula: C7H7NO3
The title compound was prepared from methyl 3-hydroxy-4-pyridinecarboxylate (495 mg; 3.232 mmol) and compound 30a (967 mg; 3.394 mmol) according to the General Procedure XXII. In order to increase yield 2 equivalents of triphenylphosphine (1.98 g; 6.788 mmol) and DIAD (1.34 mL; 6.788 mmol) were used. Purification on silica-gel column chromatography (petroleum ether/AcOEt system) afforded the title product as a white solid (1.0 g; 2.375 mmol; 73% yield). NMR (CDCb, 400 MHz) delta: 8.37 (d, J = 4.8 Hz, 1H), 8.34 (s, 1H), 7.66 (d, J = 4.6 Hz, 1H), 7.25 (AlphaAlpha’BetaBeta’, J = 6.7 Hz, 2H), 7.17 (AlphaAlpha’BetaBeta’, J = 6.8 Hz, 2H), 5.36 (d, J = 7.8 Hz, 1H), 4.21- 4.01 (m, 3H), 3.98 (s, 3H), 3.07-2.93 (m, 2H), 1.42 (s, 9H).
The synthetic route of 10128-72-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ONCOARENDI THERAPEUTICS SP. Z O.O.; MAZUR, Marzena; KORALEWSKI, Robert; BOREK, Bartlomiej; OLEJNICZAK, Sylwia; CZESTKOWSKI, Wojciech J.; PIOTROWICZ, Michal C.; OLCZAK, Jacek P.; GOLEBIOWSKI, Adam A.; BARTOSZEWICZ, Agnieszka; MAZIARZ, Elzbieta; KOWALSKI, Michal L.; (274 pag.)WO2017/37670; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem