The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1060814-91-6, name is Ethyl 2-(4-bromopyridin-2-yl)acetate. This compound has unique chemical properties. The synthetic route is as follows. name: Ethyl 2-(4-bromopyridin-2-yl)acetate
To a solution of compound 2-7 (1.3 g, 5.33 mmol, 1 eq) in dimethylformamide (2 mL) was added sodium hydride (533 mg, 13.32 mmol, 60% purity in mineral oil, 2.5 eq) at 0C under nitrogen atmosphere. The mixture was stirred at 0C for 20 minutes and methyl iodide (3.78 g, 26.63 mmol, 1.66 mL, 5 eq) was added. The mixture was stirred at 20C for 10 minutes. TLC (petroleum ether: ethyl acetate = 5:1) indicated the starting material was consumed completely and a new spot was formed. The mixture was poured into water (10 mL) and 1N hydrochloric acid (4 mL). The mixture was adjusted to pH = 8 with sodium bicarbonate solid and extracted with ethyl acetate (20 mLx3). The combined organic phase was washed with brine (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford compound 2-21 (1.44 g, 4.90 mmol, 91.92% yield) as yellow oil. LCMS: RT = 1.408 min, purity: 92.52 %, m/z 271.9,273.9 [M+H]+.1H NMR (CDCl3, 400 MHz): d 8.38 (d, J = 7.2 Hz, 1H), 7.48 (d, J = 2.0 Hz, 1H), 7.34 (dd, J1 = 7.2 Hz, J2 = 2.4 Hz, 1H), 4.17 (q, J = 9.6 Hz, 2H), 1.61 (s, 6H), 1.21 (t, J = 9.2 Hz, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 1060814-91-6.
Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.; FUSHIMI, Makoto; SCALTRITI, Maurizio; HELLER, Daniel, Alan; MONTERRUBIO MARTINEZ, Carles; ARRUABARRENA ARISTORENA, Amaia; MEINKE, Peter, T.; FOLEY, Michael, Andrew; ASANO, Yasutomi; ASO, Kazuyoshi; TAKAHAGI, Hiroki; SHAMAY, Yosef; BASELGA TORRES, Jose, Manuel; SASAKI, Yusuke; MICHINO, Mayako; (271 pag.)WO2020/72892; (2020); A1;,
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