107504-08-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107504-08-5, name is 5-Fluoro-2-picolinic acid, molecular formula is C6H4FNO2, molecular weight is 141.1, as common compound, the synthetic route is as follows.
A mixture of compound 4-1 (20 mg, 0.056 mmol), 5-fluoropicolinic acid (18 mg, 0.112 mmol), and T3P (150 mg, 0.236 mmol, 50% in EtOAc) in THF (5 mL) was stirred at 25 C overnight. The mixture was diluted with water and extracted with EtOAc. The combined extracts were washed with brine, dried over Na2S04, and concentrated. The residue was purified by preperative HPLC (column: Gemini 200×25 mm, 5 muiotaeta; mobile phases A: water containing 0.075% TFA, v/v; mobile phase B: CH3CN; gradient 18-48% B, 11 min, 25 mL/min) to afford Example 4a.
Statistics shows that 107504-08-5 is playing an increasingly important role. we look forward to future research findings about 5-Fluoro-2-picolinic acid.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CUMMING, Jared, N.; KAELIN, David Earl, Jr.; SCOTT, Jack, D.; WU, Wen-Lian; BURNETT, Duane, A.; WO2014/99794; (2014); A1;,
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