Reference of 1122-43-6 ,Some common heterocyclic compound, 1122-43-6, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of the 2,6-dimethylpyridin-3-ol (500 mg, 4.06 mmol) in DMF (15 mL) in a 50 mL flame-dried RBF, K2CO3 (0.617 g, 4.47 mmol) and MOM-C1 (0.37 mL, 4.87 mmol) were added successively. The solution was stirred at RT overnight. Water (30 mL) was added and the reaction mixture extracted with EtOAc (2 x 20 mL). The organic layer was washed with cold water (2 x 30 mL) and brine (30 mL) and dried over magnesium sulfate and concentrated under reduced pressure.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-43-6, its application will become more common.
Reference:
Patent; EMORY UNIVERSITY; MERCER UNIVERSITY; HOWARD UNIVERSITY; UNION UNIVERSITY; GUeNER, Osman; LASSEGUE, Bernard; GRIENDLING, Kathy; XU, Qian; BROWN, David; BOWEN, J. Phillip; KULKARNI, Amol; WATKINS, E. Blake; (73 pag.)WO2019/23448; (2019); A1;,
Pyridine – Wikipedia,
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