Application of 1211523-71-5, Adding some certain compound to certain chemical reactions, such as: 1211523-71-5, name is 2-(2-Bromopyridin-3-yl)acetonitrile,molecular formula is C7H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1211523-71-5.
To 0C2-(2-Bromopyridin-3-yl)acetonitrile (2.21 g, 11.21 mmol) in DMF (20 mL)Sodium hydride (60% mineral oil dispersion, 1.12 g, 28.03 mmol) was added portionwise to the solution.The reaction system was warmed to 60 C and stirred for 1.5 h.tert-Butyl bis(2-chloroethyl)carbamate (3.26 g, 13.46 mmol) was added to the mixture and stirred at 60 C for 2 h.After cooling to RT, the reaction was quenched with brine (50 mL).Extract with EA (3 x 100 mL). The combined organic phases were washed with brine (3×40 mL).Dry over anhydrous Na2SO4, filtered and evaporated.The residue was purified by silica gel chromatography eluting with EtOAc:EtOAc:4-(2-Bromopyridin-3-yl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester (1.56 g) was obtained.
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Reference:
Patent; Beijing Jiakesi Drug Discovery Co., Ltd.; Ma Cunbo; Gao Panliang; Hu Shaojing; Xu Zilong; Han Huifeng; Wu Xinping; Kang Di; Long Wei; (147 pag.)CN110143949; (2019); A;,
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