A common compound: 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide,molecular formula is C7H4F6N2O4S2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 145100-50-1
(1R)-3-bromo-2-trifluoromethylsulfoxy-1,7,7-trimethyl-bicyclo[2.2.1]heptene-2; [] To the solution of (1R)-3-bromocamphor (46.22g; 0.2 mol) in 230 ml THF 2M LDA solution (105 ml, 0.21 mol) was added drop wise at -78 C. After 30 min stirring at the same temperature a solution of 2-[N,N-bis(trifluoromethane sulfonyl)amino]pyridine (75.23g; 0.21 mol) in 80 ml of THF was added drop wise and then allowed to warm to room temperature over night. Then reaction mixture was cooled in ice bath and 250 ml of ice cold water was carefully added and product was extracted with ether (8 x 50 ml). The combined organic layers were washed with ice cold 2N NaOH, followed with brine, and dried over MgSO4/K2CO3. The residue after concentration on rotary evaporator was dissolved in 200 ml of hexane and filtered trough a shot pad of basic Al2O3. Filtrate was concentrated on rotary evaporator and the resulting oil was distilled in vacuum to give 64 g (88 %) of product as colorless oil (b.p. 73-76C/0.5 mbar).1H NMR (CDCl3) delta = 0.74 (s, 3H), 0.93 (s, 3H), 1.03 (s, 3H), 1.23 (ddd, J=12.6, J=9.2, J=3.7, 1H), 1.43 (ddd,J=12.4, J=8.9, J=3.4, 1H), 1.62 (ddd, J=12.4, J=8.5 J=3.9, 1H), 1.87 (ddt, J=12.5, J=8.6, J=3.7, 1H), 2.46 (d, J=3.7, 1H); 13C NMR (CDCl3) delta = 9.95, 18.71, 19.36, 24.96, 32.05, 56.16, 56.87, 58.72, 113.28, 118.43 (q, J=320.3), 151.99.
With the rapid development of chemical substances, we look forward to future research findings about 145100-50-1.
Reference:
Patent; Degussa AG; EP1595888; (2005); A1;,
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