Electric Literature of 162102-79-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 162102-79-6 as follows.
To a solution of dimethyl 4-bromopyridine-2,6-dicarboxylate (CAS 162102-79-6) (2.40 g, 8.8 mmol, 1.0 eq) in MeOH/DCM solution (10/1, 88 mL) was added KOH (896 mg, 8.0 mmol, 0.9 eq) at rt. The reaction mixture was stirred at rt for 3 h and Et20 (80 mL) was added thereto. The resulting white solid was filtered and then redissolved in water (50 mL). 2 M HC1 solution (8 mL) was added. The mixture extracted with DCM (2 x 50 mL). The combined organic layers were washed with brine and dried over anhydrous Na2S04. After removing the solvent, the residue as brown solid was used directly in the next step without further purification (1.0 g, Y: 44%). ESI-MS (M+H) +: 259.9. 1H NMR (400 MHz, CDC13) delta: 8.56 (d, J = 1.7 Hz, 1H), 8.50 (d, J = 1.7 Hz, 1H), 4.04 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,162102-79-6, its application will become more common.
Reference:
Patent; BIOGEN MA INC.; CHAN, Timothy; GUCKIAN, Kevin; JENKINS, Tracy; THOMAS, Jermaine; VESSELS, Jeffery; KUMARAVEL, Gnanasambandam; MEISSNER, Robert; LYSSIKATOS, Joseph; LUCAS, Brian; LEAF, Irina; DUFFIELD, Jeremy; (518 pag.)WO2016/11390; (2016); A1;,
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