Adding a certain compound to certain chemical reactions, such as: 17322-91-7, 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, blongs to pyridine-derivatives compound. Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one
Dissolve 5-hydroxy-1H-pyrrole [3,2] pyridine (10 mmol) in 40 ml of dichloromethane solution.10 ml of triethylamine was added thereto, and the temperature was controlled below 10 C.A solution of 2-chloroacetyl chloride (12 mmol) in dichloromethane was added dropwise to the system.After the addition was completed, the temperature was returned to room temperature, and the mixture was stirred at room temperature for 10 hours.The reaction system was then washed with 50 ml of a 5% aqueous solution of sodium carbonate and the organic phase was dried over anhydrous Na2SO4.After evaporating the solvent, the obtained solid was separated by flash column chromatography.1.9 g of pale yellow 2-chloro-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid were obtained in a yield of 90%.
The synthetic route of 17322-91-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sang Qi; (10 pag.)CN108456207; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem