Electric Literature of 18368-64-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18368-64-4, name is 2-Chloro-5-methylpyridine. A new synthetic method of this compound is introduced below.
2-Chloro-5-methyl-4-nitropyridine N-oxide () : Following the method of Z. Talik, A. Puszko, Roczniki Chemii Ann. Soc. Chim. Polonorum, 1976, 50, 2209, to a suspension of 2-chloro-5-methylpyridine (10 g, 0.078 mol) in acetic anhydride (25 mL), hydrogen peroxide 30% (25 mL) was added in small portions. This mixture was stirred at room temperature for 24 hours and then heated at 60 C for 30 hours. After removing the excess of acetic acid under reduced pressure, the residue was added in small portions to concentrated sulfuric acid (15 mL). The resulting solution was added to a mixture of concentrated sulfuric acid (15 mL) and fuming nitric acid (25 mL), and then heated at 100 C for 90 minutes. The reaction mixture was poured on ice, neutralized with solid ammonium carbonate and finally with aqueous ammonia until basic. A precipitate was then formed. After nitration, 10 was isolated as a pale yellow solid (9.4 g, 0. 050 mol, HPLC Rt 3.272 minutes, FIA ES+ 188.9, ES-188.0).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,18368-64-4, 2-Chloro-5-methylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2003/91246; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem