Electric Literature of 3510-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3510-66-5, name is 2-Bromo-5-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
36 g (209 mmol) 2-Bromo-5-methylpyridine and 37.5 g(418 mmol) copper cyanide are refluxed for two hours in 500 mldimethylformamide. After cooling down to50 C, 10percent aqueous ammonia solution (500 ml) is added with stirring. The product is extracted with dichloromethane, the organic phase is dried over magnesium sulfate, and the solvent is removed invacuo. The product is purified by column chromatgraphy (silica, eluent cyclohexane/ethyl acetate 9: 1). Yield: 18 g (73percentof th.)IH-NMR (300MHz, CDCIs) :8 = 2.4 (s, 3H); 7.6(m, 2H); 8.6 (s,1H) ppm.
According to the analysis of related databases, 3510-66-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER HEALTHCARE AG; WO2004/20410; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem