In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 144100-07-2, name is 2-Bromo-6-fluoropyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-Bromo-6-fluoropyridine
A mixture of 2-bromo-6-fluoropyridine (352mg, 2mmol), tert-butyl- 1 ,4-di azepane- 1- carboxylate (400mg, 2mmol), Pd2(dba)3 (91.5mg, 0.lmmol), BINAP (124.4mg, 0.2mmol), and tBuONa (3 84mg, 4mmol) in toluene (20 ml) was stirred at 80 C for 3h under N2 atmosphere. The mixture was then purified by chromatography (silica, PE/EtOAc = 5:1) to afford tert-butyl-4-(6- methylpyridin-2-yl)-1,4-diazepane-1-carboxylate (400mg, 1.3Smmol, 68%) as yellow oil. ESIMS (EI+, m/z): 296.1 [M+H]t
The synthetic route of 144100-07-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; O’NEILL, David John; SAIAH, Eddine; KANG, Seong Woo Anthony; BREARLEY, Andrew; BENTLEY, Jonathan; (565 pag.)WO2018/89433; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem