Reference of 17228-64-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17228-64-7, name is 2-Chloro-6-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.
An oven dried threaded 2 dram, 17*60 mm reaction vial equipped with a Teflon-coated magnetic stir bar is charged with [(pi-allyl)Pd(Bippyphos)]OTf (16 mg, 0.02 mmol, 2 mol %), BippyPhos (10 mg, 0.02 mmol, 2 mol %), 2-phenylindole (193 mg, 1.00 mmol), and NaOt-Bu (135 mg, 1.40 mmol). The vial is capped with a polypropylene cap with PTFE-faced silicone septum and is evacuated and backfilled with nitrogen. This evacuation/backfill cycle is repeated two additional times. Anhydrous toluene (4 mL) and 2-chloro-6-methoxypyridine (119 muL, 1.00 mmol) are added sequentially via syringe. The nitrogen needle is removed and the vial is placed on a preheated aluminum block (110 C.) and stirred for 16 hours. The tube is then removed from the heating block and allowed to cool to room temperature. The reaction mixture is diluted with 10 mL of EtOAc, filtered through a pad of Celite, and concentrated in vacuo. The residue is chromatographed on silica gel using a Teledyne ISCO CombiFlashRf with a gradient of 0-5% EtOAc/hexanes as the eluent to give 293 mg (0.98 mmol, 98%) of 1-(6-methoxypyridin-2-yl)-2-phenyl-1H-indole as a colorless oil. 1H NMR (400 MHz, CDCl3, delta): 7.75 (d, J=7.8 Hz, 1H), 7.69 (d, J=7.8 Hz, 1H), 7.55 (t, J=7.8 Hz, 1H), 7.31-7.20 (m, 7H), 6.80 (s, 1H), 6.67-6.62 (m, 2H), 3.76 (s, 3H). 13C NMR (100 MHz, CDCl3, delta): 163.7, 149.6, 140.6, 140.1, 138.4, 133.5, 129.0, 128.9, 128.3, 127.5, 123.0, 121.5, 120.8, 113.6, 111.7, 108.6, 105.6, 53.8.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17228-64-7, 2-Chloro-6-methoxypyridine.
Reference:
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas; Jon Deangelis, Andrew; (66 pag.)US9777030; (2017); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem