In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 100848-70-2, name is 2-Methoxy-4-methylpyridine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H9NO
(a); 9.2 g (69 mmol) of N-chlorosuccinimide was charged to a N,N-dimethylformamide (DMF) 15 ml solution of 8.0 g (65 mmol) of 2-methoxy-4-methylpyridine, followed by stirring for 18 hours. Water was added to the reaction solution, and the aqueous layer was extracted with diethyl ether. The organic layer was washed with a saturated sodium chloride solution, dried over anhydrous sodium sulfate and subjected to filtration, and the solvent was distilled off under reduced pressure. The crude product was purified by silica gel column chromatography to obtain 8.5 g (yield: 82%) of 5-chloro-2-methoxy-4-methylpyridine (melting point 32 to 33C). 1HNMR(CDCl3, 300 MHz): delta 2.32(s, 3H), 3.89(s, 3H), 6.62(s, 1H), 8.05(s, 1H)
The synthetic route of 100848-70-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.; EP1679003; (2006); A1;,
Pyridine – Wikipedia,
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