As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20265-37-6, name is 3-Methoxy-2-nitropyridine, molecular formula is C6H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
Step 2: A mixture of compound 32-2 (3.2 g, 20.6 mmol), Fe (5.8 g, 130.2 mmol) and AcOH (30 mL) was stirred at room temperature for lh. The mixture was filtered and to the filtrate was added Py HBr Br2. The reaction stirred at room temperature overnight. Solvent was evaporated and the residue diluted with CH3OH. The mixture was basified to pH 7 with NaHCC>3 and evaporated. The residue was purified by column chromatography (eluent: PE/EA = 2/1) to give 32-3 as a yellow oil. LC-MS: m/z = 203.0 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 20265-37-6.
Reference:
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem