Application of 22282-99-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22282-99-1, name is 4-Bromo-2-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
4-Bromo-2-methylpyridine (70 g, 407 mmol) and triethylamine (141 mL, 1.02 mol) were combined in DMF (400 mL) and MeOH (400 mL). The solution was purged with N2 for 10 minutes, and then Pd(dppf)2 (15 g, 20.35 mmol) was added. Carbon monoxide was bubbled through the mixture for 10 minutes, and then the reaction was stirred at 75 C overnight. The mixture was concentrated and the residue was diluted with 1 : 1 EtOAc:hexanes (2L) and washed 10 times with H20/brine. The aqueous layer was back-extracted 6 times, and the combined organic layers were dried, filtered, and concentrated. The residue was purified by silica gel chromatography to give the title compound.
According to the analysis of related databases, 22282-99-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; STEARNS, Brian, Andrew; ROPPE, Jeffrey, Roger; PARR, Timothy, Andrew; STOCK, Nicholas, Simon; VOLKOTS, Deborah; HUTCHINSON, John, Howard; WO2011/38086; (2011); A2;,
Pyridine – Wikipedia,
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