Adding a certain compound to certain chemical reactions, such as: 1136-52-3, (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C11H15NO3, blongs to pyridine-derivatives compound. HPLC of Formula: C11H15NO3
Anhydrous THF (200 mL) was added to NaH (60%, 24 g, 600 mmol) at 0 C under a nitrogen atmosphere. To this suspended mixture a solution of 2,2,8-trimethyl-4H-[1 ,3]dioxino[4,5-c]pyridin-5- yl)methanol (32.0 g, 150 mmol) in 400 mL of THF (J. Med. Chem. , 1977, 20, 745) was added. The resulting mixture was refluxed for 30 min; a significant amount of precipitate accumulated during the reflux. After cooling to room temperature, p-methoxybenzyl chloride (23.5 g, 150 mmol) was introduced drop-wise and the resulting mixture was refluxed for another 8 h. The reaction was quenched carefully by adding ice-cold water to the viscous mixture at 0 C and diluted with a saturated ammonium chloride solution followed by extraction with methylene chloride. The combined organic extracts were washed with brine, dried (IXfeSCU), and concentrated yielding a brown oil. The crude product was purified by chromatography (10% ethyl acetate/petroleum ether) yielding 25.0 g of Compound 9 (50% yield); LC-MS (M+H)+ m/z 331.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1136-52-3, (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; MONTREAL HEART INSTITUTE; POIRIER, Steve; STRANIX, Brent Richard; MAYER, Gaetan; (82 pag.)WO2019/84681; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem