Synthetic Route of 90902-84-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90902-84-4, name is 2,5-Dibromopyridin-3-amine, molecular formula is C5H4Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(c) 1,1-Dimethylethyl (7-bromo-2-oxo-l,2,3,4-tetrahydro-l,5-naphthyridin-3- yl)carbamate; Zinc powder (0.934 g, 14.28 mmol) and iodine (0.054 g, 0.214 mmol) were heated in an evacuated flask which was then flushed with nitrogen 3 times. Methyl N- {[(l,l-dimethylethyl)oxy]carbonyl}-3-iodo-D-alaninate (2.35 g, 7.14 mmol, Aldrich Chemicals ) was dissolved in dry DMF (11.74 mL) and transferred via syringe to the reaction mixture which was previously cooled to 00C (reaction complete after 1.5h). The ice bath was removed and 2,5-dibromo-3-pyridinamine (2.392 g, 9.50 mmol) was added followed by bis (triphenylphosphine)palladium(II) chloride (0.251 g, 0.357 mmol) and the mixture heated at 40 0C for 14h. The mixture was cooled down and filtered through Celite, washing with EtOAc. Solvent was removed in vacuum. The mixture was redisolved in DMF (10 mL) and potassium carbonate (1.283 g, 9.28 mmol) was added.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 90902-84-4, 2,5-Dibromopyridin-3-amine.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/128961; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem