In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 637348-81-3, name is 3-Bromo-5-iodopyridin-2-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C5H3BrINO
To a stirring suspension of 18 (see Example 4 above) (0.906 g, 3.0 mmol), 2-(tert-butyl-dimethyl-silanyloxy)ethanol (0.554 g, 3.15 mmol) and PPh3 (0.944 g, 3.6 mmol) in 20 mL of THF at -10 0C was added dropwise of diisopropylazodicarboxylate (DIAD) (0.728 g, 3.6 mmol) in 10 mL of THF. The ice-salt bath was removed and the reaction was kept at r.t. 2 h. The reaction solution was concentrated and purified by FC (EtOAc/Hexanes, 5/95) to afford 2-(tert-butyl-dimethyl-siianyloxy)ethoxy-3-bromo-5-iodorhoyridine, a colorless viscous liquid (0.995 g, 72%). 1H NMR £8.23 (d, IH, J= 2.0 Hz), 8.05 (d, IH, J= 2.0 Hz), 4.42 (t, 2H, J= 4.9 Hz), 3.98 (t, 2H, J= 4.9 Hz), 0.90 (s, 9H), 0.10 (s, 6H). HRMS calcd for C12H18BrINO2Si (M-CH3+), 441.9335; found, 441.9312.
The synthetic route of 637348-81-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; WO2007/126733; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem