Electric Literature of 524955-09-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 524955-09-7, name is 3-Chloro-4-(pyridin-2-ylmethoxy)aniline. This compound has unique chemical properties. The synthetic route is as follows.
0.500 g (2.14 mmol) of 3-chloro-4-(pyridin-2-ylmethoxy)aniline, 0.317 g (2.14 mmol) of 2,4-dichloropyrimidine, 0.499 g (4.28 mmol)Triethylamine and 5 mL of ethanol were added to the reaction flask and refluxed at 79 C for 6 h.After the reaction, it was cooled to room temperature. The solvent was removed by steaming under reduced pressure.Add 10mL of water,Extract with ethyl acetate (3 x 15 mL) and combine the organic phases.The organic phase is dried over anhydrous sodium sulfate and concentrated.Separated by silica gel column chromatography (dichloromethane: ethyl acetate = 1:20, V/V).Obtained as a pale yellow solid 2-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-4-chloropyrimidine0.496 g, the yield is 67%.
According to the analysis of related databases, 524955-09-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shaanxi Normal University; Li Baolin; Hao Yunxia; Zhang Yaling; Li Xiabing; Wang Wei; (22 pag.)CN109516959; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem