In 2020.0 BIOORGAN MED CHEM published article about TRANSITION-STATE ANALOG; CRYSTAL-STRUCTURE; HYDROXY COMPOUNDS; DERIVATIVES; PYRROLIDINE; BINDING; PHOSPHORYLATION; ENANTIOMERS; MECHANISM; ALCOHOLS in [Claret, Eduard Mas; Al Yahyaei, Balqees; Chu, Shuyu; Imperato, Manuel; Lopez, Arnaud; Howlin, Brendan J.; Whelligan, Daniel K.] Univ Surrey, Dept Chem, Guildford GU2 7XH, Surrey, England; [Elliott, Ruan M.] Univ Surrey, Dept Nutr Sci, Sch Biosci & Med, Guildford GU2 7XH, Surrey, England; [Meira, Lisiane B.] Univ Surrey, Dept Clin & Expt Med, Sch Biosci & Med, Guildford GU2 7XH, Surrey, England in 2020.0, Cited 66.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde
The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischaemic reperfusion or treatment with alkylating agents. A chemical probe inhibitor is required for investigations of the biological mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.
Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem