Adding a certain compound to certain chemical reactions, such as: 81719-53-1, 3,5-Dichloropyridine-2-carboxylic Acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3,5-Dichloropyridine-2-carboxylic Acid, blongs to pyridine-derivatives compound. name: 3,5-Dichloropyridine-2-carboxylic Acid
Production Example 32 (1) [0773] 5.53 ml of thionyl chloride was added to a mixture of 4.7 g of 3,5-dichloropicolinic acid, 49 ml of toluene and 0.1 ml of DMF, and the mixture was stirred at 80C for 2 hours. The cooled reaction mixture was concentrated under reduced pressure, and 49 ml of toluene, 4.84 g of N-methyl-4-trifluoromethylsulfanylaniline and 8.05 ml of diisopropylethylamine were added, and the mixture was stirred at 80C for 2 hours. The cooled reaction mixture was poured to a saturated aqueous sodium bicarbonate solution, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting residue was applied to a silica gel column chromatography to obtain 8.92 g of 3,5-dichloro-N-methyl-N-(4-trifluoromethylsulfanylphenyl)pi colinamide. RRN 1573,5-Dichloro-N-methyl-N-(4-trifluoromethylsulfanylphenyl)pi colinamide [0774] 1H-NMR(CDCl3)delta: 8.28(1H, d), 7.58(1H, d), 7.50(2H, d), 7.19(2H, d), 3.54(3H, s).
The synthetic route of 81719-53-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sumitomo Chemical Company, Limited; MAEHATA, Ryota; MIZUNO, Hajime; SHIMIZU, Chie; NOKURA, Yoshihiko; EP2881386; (2015); A1;,
Pyridine – Wikipedia,
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