Brief introduction of 39901-94-5

Here is a brief introduction to this compound(39901-94-5)Product Details of 39901-94-5, if you want to know about other compounds related to this compound(39901-94-5), you can read my other articles.

Product Details of 39901-94-5. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Anti-selective [3+2] (hetero)annulation of non-conjugated alkenes via directed nucleopalladation. Author is Ni, Hui-Qi; Kevlishvili, Ilia; Bedekar, Pranali G.; Barber, Joyann S.; Yang, Shouliang; Tran-Dube, Michelle; Lu, Hou-Xiang; McAlpine, Indrawan; Liu, Peng; Engle, Keary M..

2,3-Dihydrobenzofurans and indolines were prepared by palladium-catalyzed heterocyclization of β,γ-unsaturated amides with 2-iodophenols and 2-iodoanilines, resp., using amide N-8-quinolinyl substituent as a coordinating directing group. 2,3-Dihydrobenzofurans and indolines are common substructures in medicines and natural products. Herein, we describe a method that enables direct access to these core structures from non-conjugated alkenyl amides and ortho-iodoanilines/phenols. Under palladium(II) catalysis this [3+2] heteroannulation proceeds in an anti-selective fashion and tolerates a wide variety of functional groups. N-Acetyl, -tosyl, and -alkyl substituted ortho-iodoanilines, as well as free -NH2 variants, are all effective. Preliminary results with malonate carbon-based coupling partners as a substitute for anilines and phenols also demonstrate the viability of forming indane core structures using this approach. Exptl. and computational studies on reactions with phenols support a mechanism involving turnover-limiting, endergonic directed oxypalladation, followed by intramol. oxidative addition and reductive elimination.

Here is a brief introduction to this compound(39901-94-5)Product Details of 39901-94-5, if you want to know about other compounds related to this compound(39901-94-5), you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem