Adding a certain compound to certain chemical reactions, such as: 19798-77-7, 4-Amino-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19798-77-7, blongs to pyridine-derivatives compound. Recommanded Product: 19798-77-7
EXAMPLE 60 7-[(3-chloropyridin-4-yl)amino]-5-{[2-metlioxy-4-(piperazin-l -yl)phenyl]amino}pyrid d]pyridazin-4(3H)-one EXAMPLE 60A tert-butyl 4-(4-(7-(3 hloropyridin-4-ylamino)-4-oxo-3,4-dihydropyrido|3,4-i ]pyridazin-5- ylamino)-3-methoxyphenyl)piperazine- l -carboxylate A mixture of EXAMPLE 24A (160 mg, 0.33 mmol), 3-chloropyridin-4-amine (65 mg, 0.45 mmol), tris(dibenzylideneacetone)dipalladium (30 mg, 0.03 mmol),dimethylbisdiphenyl phosphinoxanthene (20 mg, 0.03 mmol), potassium r/-butoxide (1 12 mg, 1 mmol) and /erf-butanol (2 mL) was bubbled with nitrogen and heated at 100C for 18 hours. The mixture was concentrated and the residue was dissolved in dichloromethane, washed with saturated aqueous sodium bicarbonate and brine, dried over sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with 98/2 dichloromethane/methanol to give the title compound. MS : 579 (M + H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-77-7, its application will become more common.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem